Bromhexine tabs 8mg #20

Instruction for Bromhexine

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Composition

The composition of 1 tablet and 5 ml of syrup may include 4 mg or 8 mg of bromhexine, according to the INN (international non-proprietary name) - Bromhexine.

Form of issue

The main forms of the drug are Bromhexine tablets from 10 to 100 pieces per pack and Bromhexine syrup to 50, 60 or 100 ml in a vial.

pharmachologic effect

Antitussive, secretolitic (mucolytic), expectorant.

Pharmacodynamics and pharmacokinetics

The medicine Bromhexine is characterized by secretolitic (mucolytic) and expectorant properties, from which the tablets and syrup of the drug are used for dry cough in adults and children. The secretolitic efficacy of bromhexine is due to its ability to thin and depolymerize mucoprotein and mucopolysaccharide fibers of bronchial secretions. Also of great importance in the effectiveness of bromhexine treatment is stimulation of the formation of a surfactant, a substance of a surface active nature that lines the lungs of the lungs, thereby enhancing the protective function of the pulmonary system. In addition to its main effects, the drug has a weak antitussive effect.
Oral (ingestion) reception of bromhexine leads to its almost complete absorption (99%) of the gastrointestinal tract for 30 minutes. Due to the "first pass" effect through the liver, the drug has a low bioavailability (about 20%). Binding to plasma proteins is quite high. It is able to penetrate the placental and blood-brain barrier. Hepatic metabolic transformations pass through oxidation and demethylation. T1 / 2 due to slow reverse tissue diffusion averages 15 hours. Excretion is carried out mostly by the kidneys. Has the ability to cumulate in the body. With kidney pathologies, the excretion of metabolic products is disrupted.

Indications for use

Indications for the use of Bromhexine are the painful conditions of the bronchopulmonary system in the presence of difficult viscous sputum (tracheobronchitis, emphysema, bronchial asthma, pneumoconiosis, cystic fibrosis, bronchiectasis, tuberculosis, obstructive bronchitis, pneumonia).
Also, the drug is used in the preoperative period for sanation (recovery) of the bronchial tree; in the postoperative period for prophylactic removal of sputum congestion in the bronchi; at carrying out of diagnostic and medical clinical intrabronchial manipulations.

Contraindications

Before taking Bromhexine in tablets or syrup, you should read the contraindications to its use.
Absolute contraindications include:
    lactation;
    peptic ulcer of the gastrointestinal tract in the period of exacerbation;
    pregnancy in the first trimester;
    children age up to 2 years for syrup and up to 6 years for tablets;
    personal hypersensitivity;
    intolerance to sugars.
Carefully:
    liver / kidney pathology;
    diabetes;
    tendency to bleeding GIT;
    bronchopulmonary disease states with accumulation of excessive secretion;
    Pregnancy in the second and third trimester.

Side effects

    dyspeptic manifestations;
    nausea, vomiting;
    feeling dizzy;
    exacerbation of peptic ulcer;
    headache;
    allergic phenomena (skin rash / itching, rhinitis, Quincke's edema, etc.);
    an increase in the activity of liver enzymes.

Instructions for use Bromhexine

Bromhexine tablets, instructions for use

Bromhexine in tablets is intended for oral (oral) administration. Tablets can be taken regardless of food intake, washed down with 100-200 ml of water. Adults show a one-time intake of 8-16 mg of the drug 3-4 times per 24 hours. From 6 to 14 years old they practice a 3-time daily intake of 8 mg. The effect of therapy can develop only on 4-6 days.

Syrup Bromhexine, instructions for use

The drug syrup is mainly intended for use in pediatrics, although it does not exclude the use of the drug by adult patients in the same dosages and with the frequency of administration as prescribed for tablets (8-16 mg 3-4 times a day).
Children's syrup is produced with a mass content of active ingredient 4mg / 5ml and often is equipped with a measuring beaker for convenient dosing, such as Bromhexine Nycomed syrup, a measuring cup or a spoon.
Instructions for use Bromhexine for children recommends that patients 2-6 years of age receive 2.5-5 ml (2-4 mg); 6-10 years - 5-10 ml (4-8 mg); after 10 years - 10 ml (8 mg) of syrup for children three times a day.
Applying children's Bromhexine, it is recommended to use in parallel the vibration massage of the baby's chest or the procedure of postural drainage, in order to further facilitate the withdrawal of secretions.
The course of treatment of any of the pharmacological forms of the drug can last from 4 to 28 days. In the course of therapy, the patient should be provided with sufficient fluid to maintain a productive secretory effect.

Overdose

Symptoms of overdose may be manifested by nausea with or without vomiting, diarrhea and other disorders of a dyspeptic nature.
If an overdose is detected in the first 60-120 minutes, you should induce vomiting and rinse the stomach. Subsequently, symptomatic treatment is indicated.

Interaction

Do not prescribe in parallel with antitussive drugs (for example, codeine-containing), due to difficulty in secreting the secretion of the bronchi.
A combination with NSAIDs can irritate the gastrointestinal mucosa and even lead to the formation of erosions and ulcers.
The use of Bromhexine favors the penetration of sulfonamide drugs and antibiotics into the bronchial secret (Oxytetracycline, Erythromycin, Amoxicillin, Cephalexin), during the first 4-5 days of antibiotic therapy.

Terms of sale

You don't need a prescription to buy Bromhexine.

Storage conditions

The maximum temperature at which tablets and syrup can be stored should not exceed 25 ° C.
Shelf life - 3 years.

Children

Instruction to the drug prohibits the taking of tablets up to 6 years and the intake of syrup up to 2 years.
The main prescribed form of Bromhexine for children from 2 to 6 years of age, due to the possibility of more accurate dosing (measuring spoon or beaker) and ease of ingestion, is the oral syrup for children, used in the above dosages. The mass portion of bromhexine in tablets for children is 4 mg and is prescribed for children who have reached the age of 6 in doses corresponding to their age category.

Bromhexine in pregnancy and lactation

The drug in any form is contraindicated in pregnancy in the first trimester. In the second and third trimester, its appointment is possible only in extreme cases, consistent with the principle - benefit / risk for the mother / fetus.
If breastfeeding is necessary, Bromhexine should be stopped.

Reviews about Bromhexine

As a rule, reviews about Bromhexine of adult patients who understand what exactly the tablets of the drug are for, namely, for liquefying viscous sputum for the purpose of its prompt elimination, are of a positive nature. The drug in most cases copes well with its task and, with few exceptions, does not lead to side effects. The situation is slightly more complicated when it comes to small patients and their moms who want to cure their child's cough as soon as possible, and in case this does not happen quickly, they are ready to negatively speak about any medication. Once again we recall that the syrup for children Bromhexine is designed to solve the problem of softening of bronchial secretions, and various bronchopulmonary diseases may require therapy with different drugs from many drug groups and often in a complex. Therefore, before giving your baby any medicine, it is simply necessary to seek qualified advice from a pediatrician and strictly follow his prescriptions.