Lasolvan instruction for use
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Composition
The active ingredient of ambroxol hydrochloride (INN - ambroxol) is included in all forms of Lasolvan preparation.
Lasolvan tablets (1 pc.) Contain 30 mg of ambroxol hydrochloride, as well as additional ingredients: magnesium stearate, corn starch, lactose monohydrate, colloidal silicon dioxide.
Form of issue
Several forms of this drug are produced.
Lasolvan tablets have a white or yellowish color, a round shape. Tablets on both sides are flat, have beveled edges, on one side - engraving "67C" and risk, on the other - the symbol of the company. Tablets are packed in 10 pcs. in blisters.
pharmachologic effect
The abstract indicates that the active component of the ambroxol hydrochloride agent activates the secretion of mucus in the airways. This substance provides stimulation of ciliary activity, and also activates the synthesis of pulmonary surfactant. As a result of this action, active mucus secretion and its excretion (the so-called mucociliary clearance) is noted. Since mucus clearance is facilitated, the frequency and intensity of the cough decreases.
It was noted that in people suffering from COPD, after prolonged treatment with Lasolvan (for at least two months), the frequency of exacerbations and their duration were significantly reduced. Thanks to this treatment it was possible to reduce the duration of treatment with antibiotics.
Pharmacokinetics and pharmacodynamics
Ambroxol is absorbed quickly and almost completely. At the same time there is a linear dependence on the dose taken. When taking the dose inside, the maximum concentration is observed after 1-2.5 hours. It binds to proteins by about 90%. When administered, ambroxol in the body quickly passes from the blood into the tissues. At the same time, the highest concentration of the active ingredient of the substance is found in the lungs.
About 30% of the orally taken dose of the drug is susceptible to the effect of a "first pass" through the liver. Metabolism of the rest of the ambroxol occurs in the liver, mainly it occurs by glucuronization and partial cleavage of the substance to dibromantranilic acid and additional metabolites.
The half-life of ambroxol is approximately 10 hours.
The pharmacokinetics are not affected by the age of the patient and his sex.
Indications for use, from which tablets
The instructions indicate the following indications for the use of Lasolvan:
respiratory tract diseases, both acute and chronic, in which sputum of viscous consistency is excreted;
pneumonia;
bronchitis acute and chronic;
The bronchial asthma at which difficulties in sputum discharge are noted;
bronchiectatic disease;
COPD;
distress syndrome respiratory.
Contraindications
Such contraindications to the use of this remedy are noted:
pregnancy (first tr.);
period of breastfeeding;
The manifestation of sensitivity to any of the components of Lasagnola.
For hepatic or renal insufficiency, and also after the first three months of pregnancy, drugs are prescribed cautiously.
Side effects
As a rule, children's Lasolvan, drops for adults and other forms of medicine are well tolerated.
In the course of taking such side effects can rarely be manifested:
disorders of the digestive system, which are manifested by heartburn, dyspepsia, diarrhea, in rare cases - vomiting and nausea;
allergic reactions (a feeling of itching, urticaria, a rash on the skin);
impaired taste sensations.
Instructions for the use of Lasolvan (Method and dosage)
Lasolvan Tablets, instructions for use
Lasolvan tablets 30 mg must be taken orally on 1 table. three times a day. A different treatment regimen may be prescribed if necessary to enhance the effect: 2 tablets twice a day. It is necessary to wash down tablets with liquid, their reception does not depend on food intake. If the effect is absent for 4-5 days of treatment, you need to see a doctor.
Overdose
There is no description of overdose symptoms. There is evidence of a random overdose, resulting in negative effects in patients - development of nausea, vomiting, diarrhea, dyspepsia. If an overdose should immediately try to induce vomiting, you should also wash your stomach. These measures should be taken in the first 1-2 hours after taking Lasolvan. It is also possible to carry out symptomatic treatment.
Interaction
Provided that Lasolvan solution for ingestion and inhalation and other forms of drugs combine with antibiotics (Cefuroxime, Amoxicillin, Doxycycline, Erythromycin), then in tissues of the lungs increases the concentration of antibacterial drugs.
With the simultaneous use of Lasolvan and other medications from cough, there may be difficulty in the process of sputum discharge in view of the reduction in cough.
Terms of sale
Lasolvan can be purchased without a prescription.
Storage conditions
It is necessary to store all forms of medicine at t no more than 25 ° C, protect from children, store from light, do not freeze.
Shelf life
Store the syrup 30 mg / 5 ml, tablets and solution can be 5 years, store the syrup 15 mg / 5 ml can 3 years.
special instructions
In the solution is a preservative benzalkonium chloride. It should be borne in mind that this substance can trigger the manifestation of bronchial spasm in people who have been diagnosed with an increased respiratory tract reactivity.
The composition of the syrup includes sorbitol, so when taking this remedy there may be a mild laxative effect.
You should not take drugs to people who are marked by intolerance to fructose.
Those who adhere to a diet with a reduced sodium content, we must take into account that in the solution of Lasolvan contains 42.8 mg of sodium (at a dose of 12 ml).
There is no data on the effect of the drug on the ability to drive vehicles, and also work with precise mechanisms.
Before using the drug for children, you should visit a doctor who will tell you in detail how to take a solution or other form of medication, from which cough, and according to which scheme to use the product. Inhalations with Lasolvanom and saline are carried out only on the advice of a doctor.
Lasolvan Analogues
There are a number of drugs that are analogues of Lasolvan. At the same time, the price of analogues can be much lower. Choosing an analog for children and adults, it is necessary to take into account the recommendations of a doctor. Analogues of this agent for the active substance are preparations Ambrobene and others.
Lasolvan or Ambrobene - which is better?
Ambrobene also has an active component of ambroxol hydrochloride and is used in the case of wet cough. These drugs are produced by different manufacturers. Compared to Lasolvanom, Ambrobene has more contraindications, it causes more side effects.
What is better - Lasolvan or Erespal?
The active substance of the drug Erespal - fenspiride. This drug reduces the intensity of inflammatory processes, while Lasolvan stimulates sputum liquefaction. What preparation to choose, and whether it is possible to take Erespal and Lasolvan simultaneously, is individually determined by a specialist.
Lasolvan for children
Reviews indicate that this drug contributes to rapid sputum in children. It is important that the instructions for the syrup for children, as well as other forms of drugs are strictly observed. Pastilles are not used for children under 6 years, tablets - for people under 18 years. Lasolvan for children under one year can only be used under the constant supervision of a doctor in the form of a solution.
Inhalations are carried out according to the instructions, using any device for this. The solution is suitable for a nebulizer. Before starting the procedure, you should read the instructions on how to do inhalation with Lasolvan through a nebulizer with a dry cough in the child to do the inhalation correctly.
Lasolvan at pregnancy
Since ambroxol is able to penetrate the placenta, it is not recommended to be taken during pregnancy in the first trimester, and in the following weeks it is possible to use the remedy for treatment only under the supervision of a doctor and provided that the potential benefit exceeds the risk. When breastfeeding all forms of Lasolvana are not recommended for use.
Reviews of Lasolvan
On the forums reviews about Lasolvan in tablets are written mainly by those users who themselves used the drug for treatment. They note that with bronchitis and other diseases after the start of taking the pill, the condition was relieved in a few days. A lot of positive feedback is on the sites where children's Lasolvan are discussed. Parents often use syrup for children, as well as a solution for inhalation. In the reviews write about the rapid and effective operation of the means.
Some users write about side effects - the manifestation of allergic reactions from the skin, diarrhea.
