Bromhexine 8 dragee 8mg #25
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Instruction for Bromhexine 8Reed more and buy Bromhexine 8 on this pageComposition1 tablet (dragees) includes 8 mg of bromhexine hydrochloride, the active ingredient.Additional ingredients: magnesium stearate, gelatin, lactose mon..
Instruction for Bromhexine 8
Reed more and buy Bromhexine 8 on this page
1 tablet (dragees) includes 8 mg of bromhexine hydrochloride, the active ingredient.
Additional ingredients: magnesium stearate, gelatin, lactose monohydrate, corn starch, colloidal silicon dioxide.
Sheath: calcium carbonate, sucrose, magnesium carbonate, talc, povidone K25, macrogol, glucose syrup, titanium dioxide, carnauba wax, yellow quinoline.
Form of issue
Bromhexine 8 Berlin-Chemie is available in the form of tablets (pills), 25 pieces in a secondary package.
Secretolitic (mucolytic), secretory (expectorant).
Pharmacodynamics and pharmacokinetics
Bromhexine 8 is characterized by secretolitic (mucolytic) and secretory-motor (expectorant) efficacy, and also has a weak antitussive effect. The intake of the drug reduces the viscosity of the bronchial secretion, stimulates the cells of the ciliated epithelium, increases the amount of sputum and promotes its rapid release. In addition, the drug activates the production of endogenous surfactant, a substance that ensures the stability and productivity of the alveolar epithelium during breathing. The maximum effectiveness of therapy is observed on 2-5 days from the beginning of the drug.
With oral (oral) reception for 30 minutes, almost complete absorption of bromhexine (99%) in the digestive tract is observed. Bioavailability of the drug is at the level of 80%. With plasma proteins, bromhexine binds to 99%. Has the ability to penetrate the blood-brain and placental barriers, as well as in the milk of the nursing mother. Hepatic metabolic transformations pass through oxidation and demethylation, up to the formation of ambroxol. The average index of T1 / 2 due to the slow reverse tissue diffusion is equal to 15 hours. Excretion is performed by the kidneys (with urine) in the form of metabolites. Multiple application leads to cumulation of the drug in the human body. With CRF, the release of metabolic products is impaired.
Indications for use
The use of Bromhexine Berlin-Chemie is indicated in the case of bronchopulmonary diseases of chronic or acute course accompanied by production of viscous sputum:
emphysema of the lungs;
The intake of bromhexine is absolutely contraindicated when:
personal hypersensitivity to bromhexine and / or other components of drugs;
intolerance to sugars;
pregnancy in the first trimester;
exacerbation of peptic ulcer;
at the age of up to 6 years.
Relative contraindications are:
kidney / liver pathology;
tendency to bleeding GIT;
violations of bronchial motility with excessive concentration of secretion.
As a rule, the treatment with bromhexine is tolerated without any adverse effects.
In some rare cases, nausea / vomiting, dyspeptic symptoms, dizziness, exacerbations of peptic ulcer, dyspnea, headaches, chills, fever, as well as allergic manifestations (skin rash, swelling, rhinitis) have been observed.
Very rarely, less than 0.01% of cases, anaphylactic shock is possible.
Sometimes there was an increase in the activity of liver transaminases.
In the event that any phenomena of an allergic nature are detected, it is necessary to interrupt the intake of bromhexine and inform the physician of the observed symptoms.
Instructions for use Bromhexine 8
Instruction for Bromhexin 8 Berlin-Chemie provides oral (ingestion) tablets (dragees). Tablets should be taken in a whole form immediately after meals and washed down with 200-250 ml of water.
A single dose of Bromhexine for patients who have reached the age of 14 years is 1-2 tablets (dragees) with a three-time intake in 24 hours.
At a body weight of up to 50 kg, and also at the age of 6-14 years, a single dose is equal to the first tablet (pills) of 8 mg, with a similar frequency of receptions per day.
In the case of existing kidney / liver pathologies, a reduction in recommended dosages or a reduction in the number of doses may be necessary, which requires consultation by a physician.
The duration of the prescribed therapy is determined by the attending physician and depends on the diagnosed disease and the severity of its course. If you need treatment for more than 4-5 days, you need to consult a doctor.
For the treatment of children from 2 to 6 years, the company Berlin-Chemie produces bromhexine syrup with a dosage of 4 mg / 5 ml, which is taken three times a day for 5 ml.
When excessive doses of bromhexine were taken, life-threatening negative effects were not observed. Possible symptoms of an overdose were limited to nausea / vomiting, diarrhea, and other dyspepsia.
The recommended treatment is to cause vomiting and cleanse the digestive tract (in case of an overdose in the first 60-120 minutes). Follow-up therapy should be consistent with the observed symptomatology.
The drug is not compatible with alkaline solutions.
In connection with the difficulty of excretion of liquefied sputum, combined use of the drug with drugs that oppressively affect the cough center (including codeine-containing ones) should be avoided.
In the first 4-5 days of antibiotic therapy with Amoxicillin, Erythromycin, Oxytetracycline, Cephalexinum and Ampicillin, and simultaneous administration of Bromhexine, their penetrating ability against bronchial secretions may increase.
Terms of sale
Bromhexine preparations are allowed to leave without a prescription.
Tablets (pills) should be stored at a maximum temperature of 25 ° C.
Shelf life - 5 years.
In the process of therapy, you need to use an increased amount of fluid, which contributes to an increase in the secretolytic efficacy of Bromhexine.
For violations of bronchial motility or a large amount of sputum produced, caution should be exercised, since these states contribute to the delay of the secreted secretion.
With pathologies of the kidneys of a serious nature, cumulation of the products of Bromhexin metabolism can be observed.
In order to facilitate the removal of bronchial secretions, it is recommended that in childhood Bromhexine be combined with a vibrating breast massage or postural drainage.
The use of tablets (dragées) Bromhexine 8 Berlin-Chemie is contraindicated up to 6 years. Since 2 years you can take the syrup of this manufacturer.
In pregnancy and lactation
In the first trimester of pregnancy, the use of Bromhexine is prohibited, in the future, its use is possible only on the advice of a doctor.
In the case of taking Bromhexin in lactation, and until it is completely removed from the body, it is necessary to suspend breastfeeding.
Reviews about Bromhexine 8
In the case of using the drug for its intended purpose, namely for dilution and prompt removal of sputum, reviews on its effectiveness in the vast majority of cases are positive. The medicines of Berlin-Chemie traditionally show high results of the treatment under indications, while remaining relatively accessible and safe.