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Lasolvan Max caps 75mg #10

  • $11.18
  • 3 or more $10.99
  • Availability:In Stock

Lasolvan Max instruction for useReed more and buy Lasolvan Max on this pageComposition1 capsule containsactive substance - ambroxol hydrochloride 75 mg,excipients: crospovidone, carnauba wax, stearyl alcohol, magnesium stearate,co..

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Lasolvan Max instruction for use

Reed more and buy Lasolvan Max on this page


1 capsule contains
active substance - ambroxol hydrochloride 75 mg,
excipients: crospovidone, carnauba wax, stearyl alcohol, magnesium stearate,
composition of the capsule: gelatin, titanium dioxide (E171), iron oxide red (E172), iron oxide yellow (E172), purified water,
Ink composition: shellac, isopropyl alcohol, propylene glycol, titanium dioxide (E171).

pharmachologic effect

Drugs to eliminate cold and cough symptoms. Expectorants. Mucolytics. Ambroxol.
ATX Code R05CB06

pharmachologic effect of Lasolvan Max


Suction. Absorption is high and almost complete, linearly dependent on the therapeutic dose. The maximum temperature is 6.5 hours. Relative bioavailability is 95%.
Distribution. Distribution and extensive, with the highest concentrations in lung tissue. The volume of distribution is approximately 552 liters. The connection with plasma proteins is about 90%.
Metabolism and excretion. Approximately 30% of the dose taken internally is subjected to the effect of "first passage" through the liver.
CYP3A4 - the main enzyme responsible for the metabolism of ambroxol, under the influence of which, mainly in the liver, conjugates are formed.
The elimination half-life is 10 hours. The total clearance is within 660 ml / min, the renal clearance is 83% of the total clearance. It is excreted by the kidneys: 26% in the form of conjugates, 6% - in a free form.
Excretion of ambroxol decreases with violations of liver function, which leads to a plasma level of 1.3-2 times, but does not require correction of the dose.
Sex and age are not a dossier clinically significant effect on the pharmacokinetics of ambroxol and does not require correction before.
The intake of food does not affect the bioavailability of ambroxol hydrochloride.


Lasolvan Max has secretolitic and expectorant action; stimulates serous cells of the glands of the mucous membrane of the bronchi, increases the content of mucous secretions and the release of surfactant surfactant in the alveoli and bronchi; normalizes the disturbed ratio of serous and mucous components of sputum. By activating hydrolysing enzymes and enhancing the release of lysosomes from Clara cells, the level of sputum viscosity. Increases the motor activity of cilia of ciliated epithelium, increases mucociliary transport of sputum. Increased secretion and mucociliary clearance improves the separation of phlegm and facilitates coughing.
In patients with chronic obstructive pulmonary disease (COPD), the final treatment (6 months) There was a significant reduction in exacerbations after 2 months of treatment. In addition, weakened symptoms of the disease such as difficulty in sputum discharge, cough, shortness of breath, auscultatory symptoms compared with placebo were noted. In addition, it was noted that the disease and the need for antibiotic therapy were shorter compared with placebo.
It is proved that the local anesthetic effect of ambroxol is due to a dose-dependent blockade of the sodium channels of neurons. Under the influence of ambroxol, the release of cytokines from the blood, as well as from tissue mononuclear cells and polymorphonuclear cells, is significantly reduced.
Clinical studies on patients with sore throat showed a significant reduction in pain and redness in the throat.

Lasolvan Max, indications for use

    secretolithic therapy of acute and chronic bronchopulmonary diseases characterized by impaired secretion and difficulty in sputum discharge

Contraindications for Lasolvan Max

    hypersensitivity to ambroxol hydrochloride or other components of Lasolvan Max
    children and adolescence under 18 years

Dosing and Administration

Adults: 1 capsule once a day.
Capsule swallowed whole, squeezed with a sufficient amount of liquid.
Do not open or chew the capsule!
Granules inside the capsule secrete the active substance during passage through the digestive system.

General information.

You can take during meals or on an empty stomach.
The course is 14 days for the treatment of acute respiratory diseases and for the initial treatment of chronic conditions.
If the condition does not improve with acute respiratory disease therapy, you should seek medical help.

Side effects of Lasolvan Max

Gastrointestinal disorders
Frequently (≥ 1/100 - <1/10):
    nausea, taste change, decreased sensitivity in the oral cavity and pharynx (oral and pharyngeal hypostension)
Not infrequently (≥ 1 / 1,000 - <1/100):
    vomiting, diarrhea, indigestion, abdominal pain, dry mouth
Rarely (≥ 1 / 10,000 - <1 / 1,000):
    dryness in the throat
Immune system disorders
It is not known:
    anaphylactic reactions, including anaphylactic shock
Skin and subcutaneous tissue disorders
Rarely (≥ 1 / 10,000 - <1 / 1,000):
    rash, hives,
It is not known:
    itching and other hypersensitivity reactions, angioedema.

special instructions for Lasolvan Max

Very rare cases of severe skin lesions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported with the use of ambroxol hydrochloride. They are mainly due to the severity of the underlying disease and concomitant medication. In addition, early in the Stevens-Johnson syndrome and toxic epidermal necrosis, patients may experience signs of a nonspecific disease with the following symptoms: fever, pain all over the body, rhinitis, cough and sore throat. The appearance of these signs can lead to unnecessary symptomatic treatment of anti-cold medications. In the event of skin lesions, the patient is immediately examined by a doctor, taking ambroxol hydrochloride is stopped.
Patients with decompensated renal failure use Lasolvan Max only after consulting a doctor.

Fertility, pregnancy and lactation

Ambroxol hydrochloride penetrates the placental barrier. Preclinical studies showed no direct or indirect adverse effects on pregnancy, fetal development, childbirth and postnatal development.
It is not recommended to use the drug during the first trimester of pregnancy. Use with caution in the II-III trimesters of pregnancy and lactation.
Ambroxol hydrochloride penetrates into breast milk, however, administered at therapeutic doses, does not adversely affect the baby.
Preclinical studies showed no direct or indirect adverse effects on fertility.
Features of the effect of Lasolvan Max on the ability to drive a vehicle or potentially dangerous mechanisms
There are no reports of drug effects on the ability to drive or operate machinery in the post-marketing period. Studies have not been conducted.

Drug Interactions

No clinically significant adverse interactions with other drugs have been reported.
Joint use with antitussive drugs leads to difficulty in sputum discharge on the background of cough suppression.
Increases the penetration and concentration in the bronchial secretion of amoxicillin, cefuroxime and erythromycin.


Symptoms: nausea, vomiting, diarrhea, indigestion.
Treatment: symptomatic therapy.

Storage conditions

Store at a temperature not exceeding 30 ° C.
Keep out of the reach of children!
Shelf life - 3 years.

Terms of sell

To buy Lasolvan Max the prescription is not required.

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