Candid powder 1% 30gr

Instruction for Candid powder

You can buy Candid powder here

Composition

100 g of powder contain
active substance: clotrimazole - 1 g,
excipients: starch, colloidal silicon dioxide, cosmetic fragrance 7238, purified talc.

Description

 White or light yellow powder with a pleasant smell.

Pharmacotherapeutic group

Antifungal drugs for topical use. Imidazole derivatives. Clotrimazole.
ATH code D01AC01

Pharmacological properties

Pharmacokinetics

With external application clotrimazole is poorly absorbed through the skin. Bioavailability is less than 0.5%.
Accumulates in the stratum corneum of the epidermis at a concentration higher than the minimum inhibitory concentration (MIC) for most pathogenic fungi (50-100 µg / ml). Concentration in the basal layer of the epidermis is 1.53 - 3 µg / ml. Penetrates the keratin nails.
In the liver, it is biotransformed to inactive metabolites and excreted through the intestines.
Excreted through the kidneys (the proportion of renal excretion is 0.05% - 0.5%). The half-life of the original substance is 3.5 - 5 hours.

Pharmacodynamics

The antimycotic effect of the active ingredient clotrimazole (an imidazole derivative) is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes the subsequent lysis of the cell. In fungicide concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells. It shows fungicidal and fungistatic activity against dermatomycetes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast-like and mold fungi (Candid spp., Including Candid albicans; Torulopsis, and fungi and mold fungi, and the subject, and not to get the subject of a subject that is used by a non-human, fungi and mold fungi (Candid spp., Candid albicans; It is active against the pathogen of multi-colored lichen - Pityrosporum orbiculare (Malassezia furfur). Effective against gram-positive bacteria - the causative agent of erythrasma Corynebacterium minutissimum, as well as Staphylococcus spp., Streptococcus spp., Gram-negative bacteria - Bacteroides, Gardnerella vaginalis. In high concentrations, active against Trichomonas vaginalis.

Indications for use

- fungal infections of the skin
- interdigital fungal erosion
- Mycoses complicated by secondary infection
- versicolor versicolor
- erythrasma

Dosing and Administration

Outwardly. Apply to pre-cleaned and dry skin areas twice a day (morning and evening). Candid powder can also be sprayed onto clothing or shoes that are in direct contact with the affected areas. Candid powder can be used in combination with drugs Candid cream for external use of 1% or Candid solution for external use of 1%. The duration of therapy is individual and depends on the severity and location of the disease. To achieve complete recovery, treatment with the drug should not be stopped immediately after the disappearance of the acute symptoms of inflammation or subjective complaints. The duration of therapy should be, on average, about 3 to 4 weeks. For successful treatment, regular use of the drug is important.

Side effects of Candid powder

Rarely
- burning, tingling in places of application of the drug
- erythema, blistering, swelling, skin irritation, peeling
- pruritus, urticaria and other allergic manifestations

Contraindications

- hypersensitivity to clotrimazole or other components of the drug
- I trimester of pregnancy
- skin tuberculosis, chicken pox, herpes simplex, measles, syphilitic
 skin rashes.

Drug interactions

Clotrimazole reduces the activity of amphotericin B and other polyene antibiotics. With simultaneous use with natamycin and nystatin, the activity of clotrimazole may be reduced.

special instructions

 The drug is intended for external use only. Avoid contact with eyes.

Pregnancy and lactation

In clinical and experimental studies, it has not been established that the use of the drug during pregnancy or during lactation has a negative effect on the health of a woman or fetus (child). However, the question of the advisability of prescribing the drug in the II or III trimester should be decided individually after consulting with a doctor. When prescribing the drug during the II or III trimesters of pregnancy, it is necessary to take into account the ratio of the prospective benefit from the appointment of the drug to the mother and the possible risk to the fetus.
The penetration of clotrimazole into breast milk is not known. Care should be taken when prescribing clotrimazole to lactating women. Application of the drug directly on the lactating mammary gland is contraindicated.

Pediatric use

Children should prescribe CANDID powder only after consulting a pediatrician.
Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous machinery
Candid powder has no effect on driving or working with complex technical devices.

Overdose

Overdose is unlikely.
Symptoms: increased side effects.
Treatment: wash the affected area, symptomatic therapy.

Release form and packaging

Powder for external use, 30 g in a plastic bottle.
One bottle together with instructions for medical use in the state and Russian languages ​​are placed in a pack of cardboard.

Storage conditions

 Store in a dry, dark place at a temperature not higher than 25º C.
Keep out of the reach of children!
Shelf life - 4 years
Do not use after expiry date.

Conditions of leave from pharmacies

You don't need a prescription to buy Candid powder.