Locoid cream 0.1% 30gr

Locoid instruction

You can buy Locoid cream here

Composition

1 gram of cream includes 1 mg of hydrocortisone butyrate. In addition: 72 mg of cetostearyl alcohol, 18 mg of cetostearyl ester of macrogol 25, 60 mg of liquid paraffin, 2.8 mg of anhydrous sodium citrate, 1 mg of propyl parahydroxybenzoate, 150 mg of soft white paraffin, 0.5 mg of butyl parahydroxybenzoate, 4.2 mg of anhydrous citric acid , up to 1 g of purified water.

Form of issue

Medicinal product Locoid is produced in the form of cream and ointment of 30 grams in aluminum tubes, placed in a cardboard box.

pharmachologic effect

Local anti-inflammatory, decongestant, antipruritic.

Pharmacodynamics and pharmacokinetics

The Locoid in the form of a cream and ointment is a synthetic local (external) non-halogenated drug from the group of glucocorticoids. Due to the butirate esterification of the hydrocortisone molecule, the activity of the natural hormone that forms the basis of the drug has radically increased, which explains the rapid onset of decongestant, anti-inflammatory and antipruritic efficacy in topical application of Locoid dosage forms.
The use of the recommended therapeutic dosage of Locoide does not lead to depression of the hypothalamic-pituitary-adrenal system. The use of hydrocortisone butyrate in large doses and for a long period of time, especially when applying the drug for occlusive dressings, may be accompanied by an increase in the plasma content of cortisol, which, as a rule, does not affect the decrease in the productivity of the pituitary-adrenal system. With the discontinuation of the use of hydrocortisone butyrate, a rapid normalization of the production of endogenous cortisol is observed.
With external application of Locoid, the accumulation of hydrocortisone butyrate occurs in the epidermis, affecting mainly its granular layer. Systemic absorption of the active ingredient of the drug is insignificant and is characterized by absorption of a small amount of unchanged hydrocortisone butyrate into the systemic bloodstream.
Metabolic transformations of a significant part of hydrocortisone butyrate occur directly in the epidermis and later in the liver with the release of hydrocortisone and other metabolic products.
Excretion of a small part of the unchanged active ingredient of the preparation, as well as the products of its metabolism, is carried out with the help of the intestine and kidneys.

Indications for use

Application of ointment and cream Locoid is indicated for the treatment of superficial, uninfected skin diseases, sensitive to the effects of local glucocorticoids:
    eczema;
    Dermatitis (including seborrheic, contact, atopic);
    psoriasis.

Contraindications

Some morbid conditions of the human body are incompatible with the use of local hormonal drugs, including cream and ointment Locoid, from which they are contraindicated when:
    violations of the integrity of the epidermis (including skin wounds and ulcers);
    personal hypersensitivity to hydrocortisone or secondary ingredients of the drug;
    neoplastic transformations of the skin (malignant and benign tumors);
    bacterial skin infections (gram-negative folliculitis, staphyloderma, streptoderma, etc.);
    pinkheads (rosacea);
    viral skin infections (shingles, chickenpox, herpes simplex, etc.);
    perioral dermatitis;
    fungal skin lesions;
    acne (acne);
    parasitic skin lesions;
    syphilitic and tuberculous skin changes;
    in the post-vaccination period;
    in infancy up to 6 months.
Special care for the appointment of Locoid requires pregnant and lactating women.

Side effects

In some cases, the use of therapeutic doses of Locoid observed the formation of adverse local reactions, manifested by skin irritation or other local phenomena characteristic of external therapy with glucocorticoids.
In the case of prolonged use of Locoid, application of the dosage forms of this drug to occlusal dressings and / or to large skin surfaces, occasional side effects characteristic of the action of systemic glucocorticoids were noted.
With external use of Locoid, the risk of developing local and systemic negative side effects is significantly lower than with fluorinated steroids.

Instructions for use Locoid (Method and dosage)

Cream Locoid, instructions for use

Cream Locoid is intended for local (external) use mainly for the treatment of subacute and acute negative skin processes.
Depending on the location and severity of skin lesions, 1-3 times a day applying a thin layer of cream to the problem areas of the skin is indicated. In order to improve the penetration of the cream into the epidermis, its application should be carried out with light massaging movements of the palms of the hands. If there is a positive dynamics of therapy, the frequency of the use of the cream can be reduced to 2-3 times in 7 days. The total weekly dose of the drug should not exceed 30-60 grams.

Overdose

Descriptions of actual episodes of an overdose when using any of the medicinal forms of Locoid are not present. With prolonged use of excessive amounts of the drug, there may be an increase in the above described adverse side effects or their occurrence. In the case of the appearance of symptoms of hypercorticism, the treatment should be stopped.

Interaction

There is no confirmed data on any drug interaction of Locoid.

Storage conditions

Locoid preparations should be stored in the factory tube at ambient temperatures up to 25 ° C.

Shelf life

Cream preparation retains its properties for 3 years; ointment for 5 years.

special instructions

Due to the risk of formation of glaucoma, any kind of Locoid dosage form should be avoided on the periorbital area.
In the case of a systematic ingestion of the active ingredient of the drugs, the intraocular pressure may increase on the conjunctiva.
A Locoid in the form of an ointment is preferably not used for the treatment of acute inflammatory processes (especially exudative), as well as skin diseases of the scalp. For the therapy of steroid-sensitive skin lesions localized in the area of ​​folds, abundant hair, face and genitalia, it is better to use other local medicinal forms of the drug Locoid (Krlo or cream).
It is undesirable to appoint Locoid in the presence of changes in the skin of an atrophic nature.
The possibility of occurrence of systemic and local side effects inherent in hydrocortisone increases with its long-term use, application of the drug for occlusive dressings or extensive skin areas, as well as in childhood.
In the absence of the effect of therapy with continuous use of Locoid for 2 weeks, the doctor should clarify the diagnosis.
The duration of use of the Locoid is best limited to the minimum possible time, with the appointment of a course dosage sufficient to stop the negative skin process.

Children

The possibility of using Locoid in pediatrics is considered from 6 months of age. The area of ​​the skin surface of the child's body used for the application of drugs should not occupy more than 20% of the total area. When applying Locoid under occlusive dressings or applying it on the face area of ​​a child, the duration of the therapeutic course should be shortened to the minimum possible time.
It should be remembered that in the children's age group oppression of the function of the adrenal cortex can occur more quickly. Above this, local hormone therapy can cause a decrease in the production of growth hormone in children. In case of prolonged use of Locoid in pediatrics, it is necessary to monitor the body weight of the child, its growth indices and the plasma level of cortisol. In the studies, children who received 30-60 grams of Locoid per week for a month, compared to children receiving 1% hydrocortisone ointment, did not undergo any change in the functionality of the adrenal cortex.

In pregnancy and lactation

The appointment of Locoid to pregnant and lactating women requires special care.
Since glucocorticoids have the property of penetrating the placenta, they are allowed to affect the fetus, especially when applying the drug to extensive skin areas.
The exact amount of hydrocortisone in breast milk is not established, and therefore it is not possible to determine the extent of its effect on the baby.

Reviews about Locoid

The feedback on the Locoid ointment shared by the Internet has divided the patients ever using this drug approximately equally, some of them note the high effectiveness of the ointment, its quickness and the absence of side effects, while others assess the effect of the drug "to the contrary". Reviews about Locoid cream are more positive. In this case, the number of people who remained satisfied with the effects of the cream, far exceeds the number of patients with negative opinions about its effects. This may be due to the use of an ointment or cream to treat non-inherent skin diseases. In any case, the use of even external hormonal drugs requires a thorough approach with an accurate diagnosis and selection of a therapeutic agent.
The same tendency to assess the effectiveness and safety of Locoid is traced when it is used in pediatrics, regardless of the dosage form of the drug, including cream or ointment. Hormonal or not the basis of the local medicinal product, the possibility of its use for children can be established exclusively by a pediatrician, treating each individual pathological case individually.