Locoid ointment 0.1% 30gr

Locoid ointment instruction for use

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Composition

Active component:
Hydrocortisone-17 butyrate
Excipients:
95% vaseline oil, 5% polyethylene glycol

pharmachologic effect

Local anti-inflammatory, anti-edematous, antipruritic.

Pharmacodynamics

Locoid ointment is a synthetic non-halogenated glucocorticosteroid agent for external use, which has increased activity due to the esterification of hydrocortisone molecules with butyrate. It has anti-inflammatory, antipruritic, anti-edema, vasoconstrictor, immunosuppressive effect. Slows down the processes of formation and division of keratinocytes, reduces the percutaneous penetration of microorganisms and allergens, and also significantly slows down the loss of water, preventing the development of xerodermia.
In the recommended doses, it does not inhibit the activity of the hypothalamic-pituitary-adrenal system. At the same time, prolonged use of the drug (including the application of occlusive dressings) may cause an increase in plasma cortisol levels. After discontinuation of the drug, the condition is completely normalized.

Pharmacokinetics

After applying to the skin, Locoid turns into hydrocortisone 21 butyrate. The drug accumulates in the granular epidermal layer, further disintegrating into hydrocortisone and butyric acid. After absorption into the skin, the ointment is completely metabolized in the liver and does not cause systemic reactions. Pharmacological effects of the drug are limited to the epidermis. Its metabolites are excreted along with urine, and, in small quantities, along with feces.

Indications for use

    Dermatitis (contact, atopic, seborrheic);
    Eczema;
    Psoriasis.

Contraindications for Locoid ointment

    Individual intolerance and hypersensitivity to the individual components of the drug;
    The presence of skin bacterial infections (gram-negative folliculitis, streptoderma, staphyloderma);
    Skin fungal infections;
    Skin viral infections;
    Syphilitic and tuberculous lesions of the skin;
    Perioral dermatitis, acne, rosacea;
    Benign and malignant neoplasms on the skin;
    Skin parasitic infections;
    Violation of the integrity of the skin (a consequence of injury).

Dosage and administration

Locoid, an ointment for external use, is used in the presence of dryness, infiltration or lichenification. The drug is recommended to be applied to the affected skin 1-3 times a day with a thin layer. If a positive trend occurs, the use of the drug should be reduced to 2-3 times a week. In the treatment of psoriasis, accompanied by the formation of dense plaques on the elbows and knees, the ointment should be applied under occlusive dressings.
Note: the weekly dose of the drug should not exceed 30-60 grams.

Drug interaction

The agent used for outdoor use does not interact with other pharmacological products.

Side effects of Locoid ointment

Local adverse reactions: skin irritation, rosace-like dermatitis, atrophic changes (wrinkled, shiny skin, visible vascularization), telangiectasia, hypertrichosis, depigmentation, slow wound healing.
After prolonged use of the drug, after the cessation of its application, the development of the phenomenon of withdrawal is possible, which is characterized by exacerbation of dermatitis. With the hour of contact of Locoid with the conjunctiva of the eye, there is a risk of developing cataracts, an increase in intraocular pressure is noted.
Systemic adverse reactions: suppression of the functional activity of the adrenal glands

Overdose

Currently, there are no reports of overdose cases.

special instructions

The drug is not recommended to be applied on the scalp or periorbitral area, use in the presence of acute exudative inflammation. When treating skin lesions localized in the external genital area, on the face and in large skin folds it is more expedient to use other dosage forms of this drug.
If there is no effect after two weeks of applying the ointment, an additional differential diagnostic test is required.
The drug is approved for use in pediatrics from 6 months of age. The area of ​​application of the drug should not exceed 20% of the total body area of ​​the child. In childhood Locoid should be used with extreme caution, as it can lead to suppression of the function of the adrenal cortex and a decrease in the secretion of growth hormone.
If you experience symptoms of hypercortisolism, the use of the drug should be immediately discontinued.
There are no data on the effect of the ointment on the ability to drive a car or to perform work requiring increased attention concentration and quickness of psychomotor reactions.

Storage conditions

Store in a dry, protected from light, out of reach of children, at a temperature not exceeding 25 C. Storage life is 5 years. At the end of this period, the drug is prohibited.

Terms of sell

You don't need a prescription to buy Locoid ointment.