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Loratadine syrup 5 mg / 100 ml

  • $9.47
  • Availability:In Stock

Loratadine syrup instuction for useYou can buy Loratadine syrup heregeneral characteristicsinternational and chemical names: loratadine; 4- [8-chloro-5,6-dihydro-1 [H-benzo [5,6] cyclohepta [1,2-v] pyridin- [1-ylidene] -1-piperidi..

Tags: syrup

Loratadine syrup instuction for use

You can buy Loratadine syrup here

general characteristics

international and chemical names: loratadine; 4- [8-chloro-5,6-dihydro-1 [H-benzo [5,6] cyclohepta [1,2-v] pyridin- [1-ylidene] -1-piperidinecarboxylic acid ethyl ester;
basic physical and chemical properties: colorless or slightly yellowish, or slightly greenish-yellowish liquid with a specific odor;
composition: 5 ml of syrup contains - 5 mg of loratadine;
auxiliary substances: refined sugar, citric anhydrous acid, sodium benzoate, propylene glycol, glycerin, food aroma "Apricot 059", purified water.
Form of issue. Syrup.

Pharmacotherapeutic group

Antihistamines. ATS code R06A X13.

Pharmacological properties

Pharmacodynamics. Loratadine is a tricyclic piperidine compound with a pronounced antihistamine effect; has selective antagonism with respect to peripheral histamine H1-receptors. Loratadine is a long-acting drug that exhibits a complex effect, including antiallergic, antipruritic and antiexcudative activity, reduces permeability of capillaries, prevents the development of edema of tissues, eliminates spasms of smooth muscles. The drug and its metabolites do not penetrate the blood-brain barrier. Loratadine does not have a sedative effect.

Pharmacokinetics. After ingestion, the drug is found in the blood after 15 to 20 minutes. The maximum concentration of Loratadine and its metabolite of decarboxetoxyloratadine in plasma is observed after 1 hour and persists to 36-48 hours. Approximately 97% of Loratadine binds to plasma proteins. The drug penetrates into breast milk, is excreted in urine and feces.

Indications for use

Allergic rhinitis (seasonal and year-round), allergic conjunctivitis, acute and chronic urticaria, Quincke's edema, allergic reactions to insect bites, pseudoallergic reactions to histamine-liberators, as well as contact allergic dermatitis and chronic eczema.

Dosing and Administration

The drug is administered to adults and children older than
12 years - 10 mg 2 teaspoons (10 ml) once a day, children aged 2 to 12 years with a body weight of less than 30 kg - 5 mg 1 teaspoon (5 ml), with a body weight of more than 30 kg - 10 mg 2 teaspoons (10 ml) once a day. The course of treatment is 5-10 days.

Side effect

In the application of Loratadin in isolated cases, headache, dry mouth, drowsiness, nausea, allergic reactions in the form of a rash can be observed.


Hypersensitivity to loratadine or some other component of the syrup. Children up to 2 years.


When the therapeutic doses of Loratadine exceed 4 and more times, the risk of side effects increases: drowsiness, tachycardia and headache.

Application features

Loratadine is not a sedative antihistamine, but some patients may have a dose-dependent sedative effect. The drug should be administered with caution to persons whose work is related to the management of transport or other mechanisms. In patients with impaired liver function or renal insufficiency, the initial dose of the drug should be 10 mg (2 teaspoons of syrup) every other day. During pregnancy and lactation, the drug should be used only if the therapeutic effect of its use in the mother exceeds the potential risk to the fetus or newborn.

Interaction with medicines

With the simultaneous use of loratadine with cimetidine, erythromycin, ketoconazole, it is possible to increase its serum concentration caused by a disruption in the metabolism of Loratadin, probably due to the inhibition of cytochrome isoenzyme CYP3A4
P-450. In connection with the possible development of a dose-dependent sedative effect, caution should be exercised while using Loratadine with other H1 receptor blockers, barbiturates, benzodiazepines, opioid receptor agonists, neuroleptics, tricyclic antidepressants, sedatives and hypnotics.

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