Otrivin 0.1% 10ml

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Otrivin instruction

Composition

The composition of 1 ml drops and spray Otrivin, as an active ingredient, is 0.5 mg or 1 mg xylometazoline hydrochloride.
Auxiliary ingredients of drops and spray: dihydrophosphate sodium dihydrate, edetate disodium, sodium dodecahydrate hydrophosphate, benzalkonium chloride, sorbitol, sodium chloride, hypromellose 4000, purified water (optional for menthol and eucalyptus spray - levomenthol and eucalyptol).

Form of issue

The therapeutic agent Otrivin is produced in the form of 0.1% or 0.05% drops and a dispensed spray of 10 ml per package.

pharmachologic effect

Vasoconstrictive, anticonvulsant.

Pharmacodynamics and pharmacokinetics

Xylometazoline is a drug belonging to the group of decongestants, which have local vasoconstrictive efficacy, which is why they are widely used in ENT practice. The drug has a pronounced alpha-adrenomimetic effect. Local application of xylometazoline to the nasal mucosa and nasopharynx leads to a narrowing of the blood vessels in them, as well as the elimination of hyperemia and swelling and, as a consequence, to the relief of nasal breathing in the painful conditions occurring with nasal congestion (rhinitis).
Xylometazoline has a balanced pH characteristic of the nasal cavity and is well tolerated by patients with sensitive mucous membranes. The anticongestive action of the drug does not prevent the nasal mucus from escaping.
Additional ingredients of droplets and spray - hypromellose and sorbitol - act as additional moisturizers, which allows to reduce the manifestations of dryness and irritation of the mucous membranes, observed with prolonged use of xylometazoline.
Levomenthol and eucalyptol, included in the spray with menthol and eucalyptus, have a cooling and refreshing effect.
The use of the drug in therapeutic dosages does not cause hyperemia and does not lead to irritation of mucous membranes. The pharmacological efficacy of xylometazoline is observed after a few (3-5) minutes after its local use and is observed for 12 hours.
Absorption of xylometazoline with its local application actually tends to zero, and its plasma content is so small that it can not be determined using existing analytical methods.

Indications for use

The use of drops or spray is indicated when:
    the observed average otitis (with the aim of reducing edema of the mucous nasopharynx);
    diagnosed acute respiratory diseases, which occur with manifestations of rhinitis (rhinitis);
    eustachites;
    acute rhinitis of allergic etiology;
    allergic seasonal rhinoconjunctivitis;
    sinusitis;
    preparation of the patient for diagnostic procedures in the nasal passages.

Contraindications

The administration of any of the pharmacological forms of Otrivin is contraindicated when:
    atrophic rhinitis;
    arterial hypertension;
    hyperthyroidism;
    tachycardia;
    states after transsphenoidal hypophysectomy;
    severe atherosclerosis;
    surgical operations on the membranes of the brain (in the anamnesis);
    glaucoma;
    increased personal sensitivity to the ingredients of drugs;
    at the age of up to 1 year (for 0.05% of drugs), up to 12 years (for 0.1% of drugs).
With special care, it is possible to prescribe any of the medicinal forms of Otrivin when:
    pregnancy;
    diabetes mellitus;
    breastfeeding;
    cardiovascular pathologies;
    prostate adenoma;
    increased sensitivity to the effects of adrenergic drugs, taking place with an increase in blood pressure, insomnia, arrhythmia, dizziness, tremor.

Side effects

Local reactions from the mucous membranes (most often observed with frequent and / or prolonged use):
    hypersecretion;
    dryness and / or irritation;
    a feeling of tingling or burning;
    sneezing;
    swelling.
Reactions of a systemic nature (most often observed with frequent and / or prolonged use):
    nausea, vomiting;
    blurred vision;
    headache;
    tachycardia;
    allergic manifestations;
    a feeling of palpitations;
    insomnia;
    arrhythmia;
    dizziness;
    increased blood pressure;
    depressive states.

Instructions for use Otrivin

Drops, instructions for use
Prior to the use of drops, the nasal passages should be thoroughly cleaned, for which it is recommended to use agents in the form of a cleaning spray containing sea water, for example, Otrivin More.
Otrivin drops in the nose 0.1% are designed to treat patients who have reached 12 years of age. One-time in each nasal passage, you can drip 2-4 drops. In a day, this procedure can be carried out no more than 3 times. The therapeutic course should not exceed 10 days.
Instruction for Otrivin children in the form of 0.05% drops recommends their use for therapy of children 1-12 years old, under the supervision of adults. At the age of 1-6 years, 1-2 single instillations of 1-2 drops in each nasal passage are shown per day, with a duration of treatment not exceeding 7 days. At the age of 6-12 years, you can dig in children's Otryvin 2-4 drops in each nasal passage 2-3 times in 24 hours. The duration of treatment should be limited to 7-10 days.

Spray Otrivin, instructions for use

Just like using drops, before using the spray, it is necessary to clean the nasal passages with Otrivin More spray or another similar preparation containing sea water.
Patients over 12 years of age are recommended to use a 0.1% spray. In each nasal passage, with a frequency no more than 3 times a day, one injection is made. The duration of therapy should not exceed 10 days.
Spray for children 0.05% is indicated for the purpose from 1 to 12 years, under the supervision of adults. Children 1-6 years old are recommended 1 injection procedure in each nasal passage, with a frequency of 1-2 times in 24 hours. Patients 6-12 years can be given single injections in each nasal passage 2-3 times a day. The duration of treatment is best limited to 7 days.

Overdose

When using overpriced Otrivine dosage or its use for more than the recommended time, there may be side effects inherent in the drug, or an increase in the already observed negative phenomena: increased heart rate, increased blood pressure, and occasionally confusion.
The treatment for such complications should be consistent with the observed negative symptoms.

Interaction

Medications containing xylometazoline should not be used in therapy with tricyclic antidepressants or MAO inhibitors.
Local application of xylometazoline can potentially affect the effects of certain antihypertensive drugs, such as β-blockers.

Terms of sale

Purchase of drops and spray Otrivin does not require a prescription.

Storage conditions

Store any of the pharmaceutical forms of the drug should be at an ambient temperature of up to 25 ° C.

Shelf life

All dosage forms of Otrivin can be used for 3 years from the date of their manufacture.

special instructions

Both drops and spray Otrivin should not be used for more than 10 consecutive days. Excessive and / or prolonged use of the drug may cause stagnant reactive effects and / or atrophy of nasal mucosa.
Care should be taken to prescribe this medication with respect to patients strongly reacting to the effects of adrenergic drugs, including insomnia, increased blood pressure, tremor, dizziness, and cardiac arrhythmia.
Avoid exceeding the recommended dosages of Otrivin, especially when treating elderly patients and children.
A careful prescription of the drug is required for patients suffering from cardiovascular pathologies, diabetes mellitus, arterial hypertension, pheochromocytoma, prostate adenoma, porphyria and thyroid pathologies.
A vial with drops or a spray is intended solely for use by one patient, because of the possible spread of the infection.
Benzalkonium chloride, included in the preparation, can irritate the nasal mucous membranes.

Analogues

Analogues of the drug in the form of drops or spray, the main effects of which are identical to the effect of Otrivin:
    Tyzine;
    Naphthyzin;
    Sanorin; etc.

Children

All 1% dosage forms of the drug can be given to children only after reaching the age of 12 years. The instruction to the drug allows the use of Otrivin for children aged 1-12 years, exclusively at a dose of 0.5 mg / 1 ml (0.05%), under the supervision of adults and without exceeding the recommended dosages. Reviews about the spray for children left by ENT doctors, talk about the advisability of using this form of the drug to treat children after 6 years, whereas younger children (1-6 years) are recommended to appoint 0.05% drops.

During pregnancy and lactation

Drops and spray of this drug are not recommended for pregnant women. In the case of acute need to get rid of manifestations of rhinitis, the attending physician can prescribe the child Otryvin during pregnancy (0.05%), but under strict control and in minimal dosages.
If, during breastfeeding, there is a need for the use of Otrivin, its administration is possible in minimal doses and only if the benefits of treatment are unambiguously exceeded, in comparison with the possible risks for the infant.

Reviews about Otrivin

In the case of using drops and spray Otrivin strictly according to the indications and in the recommended dosages, reviews about its effectiveness and safety are mostly positive. Adult patients who use this drug, note the speed and duration of its action and very rarely observe any side effects.
Reviews about the children of Otrivin often leave the parents, on their experience experienced his action in relation to their children. The drops of this drug perfectly cope with the symptomatology of the common cold in children from the age of 1 and in the recommended doses do not lead to the formation of any side effects. The same parents note that the spray for children Otrivin is more suitable for the treatment of adolescents, where this dosage form is more expedient to use than drops.